Treatment of Epilepsy (3rd Edition)

Treatment of Epilepsy (3rd Edition)

Simon Shorvon, Emilio Perucca, Jerome Engel (Editors) 
Wiley-Blackwell, Oxford (2009). | ISBN 978-1-4051-8383-3 | pp 1200

This is a textbook of epilepsy treatment, in its third edition and considered a standard reference work worldwide. Its primary objective is to provide a systematic review of the whole field of contemporary therapy in epilepsy. The emphasis is, as before, on a text that provides practical information, useful for the clinician but which is comprehensive, accurate and concisely given. The basic purpose of the book to guide clinical practice and rational therapy, and to be a source of reference for clinicians at every level.

The book has a new editor and has increased in size from 63 in the first edition, to 74 in the second and to 85 in this edition. There are 26 completely new chapters, as well as extensive updating of the others. There are 90 new authors, joining the 53 who contributed to both this and the previous edition. The new chapters reflect the significant changes which have been made to the principles of, and approaches to, epilepsy therapy, the introduction of new drugs and the development of new surgical techniques.

The three editors are, or have been, long-standing members of the ILAE executive and almost all of the lead authors of the chapters of our book are involved deeply in the league. Indeed, contributors to the book are from 17 countries in all five continents, reflecting the global reach.

In the historical introduction to this edition, the historical survey of drug therapy in epilepsy is continued, bringing this up to the year 1989. In the previous two editions, the survey covered the years 1857– 1938 and then 1938–1955. Here, the story is advanced by 35 important years to 1989, and is written from the particular perspective of the ILAE.


Forword, xv
Preface to the Third Edition, xvii
Historical introduction: History of the Drug Treatment of Epilepsy Between 1955 and 1989 with Special Reference to the Role of the International League Against Epilepsy (ILAE), xxi
Simon Shorvon

Section 1 – Introdution
1. Definitions and Classification of Epilepsy, 3 1
Christina A. Gurnett and W. Edwin Dodson

2. Epidemiology and Prognosis of Epilepsy, 21
Lars Forsgren and Dale Hesdorffer

3. Aetiology of Epilepsy, 33
Simon D. Shorvon

4.Differential Diagnosis of Epilepsy, 55
Mark Cook

5. Mechanisms of Epileptogenesis, 67
Giuliano Avanzini and Silvana Franceschetti

6.Antiepileptic Drug Discovery, 81
H. Steve White

7. Mechanisms of Antiepileptic Drug Action, 91
Matthew C. Walker, Rainer Surges and Andrew Fisher

8. Mechanisms of Tolerance and Drug Resistance, 109
Wolfgang Löscher and Dieter Schmidt

Section 2 – Principles of Medical Management
9. General Principles of Medical Management, 121
Emilio Perucca

10 Management of Newly Diagnosed Epilepsy, 141
Yvonne M. Hart

11 Management of Chronic Active Epilepsy in Adults, 153
Simon D. Shorvon

12 Management of Epilepsy in Remission, 163
Patrick Kwan and Howan Leung

13 Management of Epilepsy in Infants, 171
Catherine Chiron

14 Management of Childhood Epilepsy Syndromes, 179
Colin D. Ferrie

15 Management of Epilepsies Associated with Specific Diseases in Children, 195
John H. Livingston

16 Management of Epilepsy in the Elderly, 203
Hiba Arif, Anil Mendiratta and Lawrence J. Hirsch

17 Management of Epilepsy in People with Learning Disabilities, 219
Eylert Brodtkorb

18 Emergency Treatment of Seizures and Status Epilepticus, 231
Matthew C. Walker and Simon D. Shorvon

19 Traumatic Brain Injury and Other Risks, 249
Marc Dichter and Nancy R. Temkin

20 Management of Medical Co-morbidity Associated with Epilepsy, 259
Gagandeep Singh

21 Psychiatric Features of Epilepsy and their
Brent Elliott, Meriem Amarouche and Simon D. Shorvon

22 Management of Side-effects of Antiepileptic Drugs, 28
Gaetano Zaccara, Fabrizio Balestrieri and Aldo Ragazzoni

23 Ketogenic Diets, 301
Eric H. Kossoff and Jennifer L. Dorward

24 Non-pharmacological, Complementary and Alternative Treatments for Epilepsy, 311
Tom Whitmarsh

25 Reproductive Aspects of Epilepsy Treatment, 323
Torbjörn Tomson

26 Epilepsy Counselling, 335
Anthony Linklater, Doreen Patsika and Susan Usiskin

27 Genetic Counselling in Epilepsy, 341
Federico Zara

28 Drug Interactions, 361
Edoardo Spina

29 Medical Treatment of Epilepsy in Situations with Limited Resources, 379
Gretchen L. Birbeck

Section 3 – Antiepileptic Drugs
30 Introduction to the Choice of Antiepileptic Drugs, 389
Emilio Perucca

31 Acetazolamide, 399
Miri Y. Neufeld

32 Adrenocorticotropic Hormone and Corticosteroids, 411
Federico Vigevano and Maria Roberta Cilio

33. Benzodiazepines used Primarily for Chronic Treatment (Clobazam, Clonazepam, Clorazepate and Nitrazepam), 459
Peter Camfield and Carol Camfield

34 Benzodiazepines used Primarily for Emergency Treatment (Diazepam, Lorazepam and Midazolam), 469
Eugen Trinka

35 Brivaracetam, 421
Philipp von Rosenstiel and Emilio Perucca

36 Carbamazepine, 443
Matti Sillanpää, Leena Haataja, Torbjörn Tomson and Svein I. Johannessen

37 Carisbamate, 433
Gerald P. Novak and Martin J. Brodie

38 Eslicarbazepine Acetate, 485
Luis Almeida, Meir Bialer and Patricio Soares-da-Silva

39 Ethosuximide, 499
Tracy A. Glauser and Emilio Perucca

40 Felbamate, 511
Ilo E. Leppik and James R. White

41 Gabapentin, 519
Ernest R. Somerville and Andrew W. Michell

42 Lacosamide, 527
Rajesh Sachdeo

43 Lamotrigine, 535
Fumisuke Matsuo and Awais Riaz

44 Levetiracetam, 559
Jacqueline A. French and Françoise Tonner

45 Oxcarbazepine, 575
Edward Faught and Nita Limdi

46 Phenobarbital, Primidone and Other Barbiturates, 585
Roberto Michelucci, Elena Pasini and Carlo Alberto Tassinari

47 Phenytoin, 605
Mervyn J. Eadie

48 Piracetam, 619
Simon D. Shorvon

49 Pregabalin, 627
Sylvain Rheims and Philippe Ryvlin

50 Retigabine, 637
Harry Mansbach and Michel Baulac

51 Rufinamide, 647
Victor Biton

52 Stiripentol, 657
Kai Eriksson and Tapani Keränen

53 Tiagabine, 663
Reetta Kälviäinen

54 Topiramate, 673
J. Helen Cross and Catherine J. Riney

55 Valproate, 685
Blaise F.D. Bourgeois

56 Vigabatrin, 699
Günter Krämer and Gabriele Wohlrab

57 Zonisamide, 713
Stephen J. Wroe

58 Other Drugs Rarely Used, 721
Hartmut Meierkord and Martin Holtkamp

59 Antiepileptic Drugs in Early Clinical Development, 733
Philip N. Patsalos and Josemir W. Sander

Section 4 – Presurgical Assessment and Epilepsy Surgery
60 Overview of Surgical Treatment for Epilepsy, 743
Jerome Engel Jr

61 Scalp EEG in the Epilepsy Surgery Evaluation, 757
Christine Bower Baca and John M. Stern

62 Invasive EEG in Presurgical Evaluation of Epilepsy, 767
Susan S. Spencer, Dang K. Nguyen and Robert B. Duckrow

63 MEG in Presurgical Evaluation of Epilepsy, 799
Hermann Stefan, Stefan Rampp and Rüdiger Hopfengärtner

64 MRI in the Presurgical Evaluation, 805
Jörg Wellmer and Christian E. Elger

65 PET and SPECT in Presurgical Evaluation of Epilepsy, 821
Wim Van Paesschen, Karolien Goffin and Koen Van Laere

66 Experimental Neurophysiological Techniques, 829
François Mauguière, Isabelle Merlet and Julien Jung

67 Neuropsychological Testing in Presurgical Evaluation, 851
Marilyn Jones-Gotman and Jelena Djordjevic

68 Presurgical Psychiatric Evaluation, 865
Andres M. Kanner

69 Mesial Temporal Lobe Surgery and Other Lobar Resections, 875
James Leiphart and Itzhak Fried

70 Resective Surgery of Neoplasms, 887
Nicholas Wetjen, Mithri R. Junna, Kurupath Radhakrishnan, Aaron Cohen-Gadol and Gregory D. Cascino

71 Resective Surgery of Vascular and Infective Lesions for Epilepsy, 903
Christopher E. Uff and Neil D. Kitchen

72 Surgery of Developmental Anomalies Causing Epilepsy, 925
Joshua Chern and Youssef G. Comair

73 Hemispherectomy for Epilepsy, 935
Georg Dorfmüller, Christine Bulteau and Olivier Delalande

74 Corpus Callosotomy, 943
David W. Roberts

75 Hypothalamic Hamartoma and Multiple Subpial Transection, 951
Michael C. Smith, Richard Byrne and Andres M. Kanner

76 Awake Surgery for Epilepsy, 959
Christian B. Kaufman and Webster H. Pilcher

77 Epilepsy Surgery in Children, 967
Jason S. Hauptman and Gary W. Mathern

78 Stereotactic Surgery for Epilepsy, 975
Andrew W. McEvoy and Fiona J.L. Arnold

79 Complications of Epilepsy Surgery, 993
Charles E. Polkey

80 Anaesthesia for Epilepsy Surgery, 1007
Barbara Van de Wiele

81 Vagal Nerve Stimulation, 1017
Steven C. Schachter

82 Brain Stimulation, 1025
Gregory K. Bergey

83 Stereotactic Radiosurgery for Medically Intractable Epilepsy, 1035
Isaac Yang, Edward F. Chang and Nicholas M. Barbaro

84 Future Focal Treatment Approaches to Epilepsy, 1043
Hannah R. Cock and Karen E. Nilsen

85 Epilepsy Surgery in Countries with Limited Resources, 1051
Andre Palmini

Index, 1057

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