Edited by: Simon D. Shorvon, Frederick Andermann, Renzo Guerrini 

Cambridge University Press, Cambridge. 

ISBN 978-1-4051-8383-3 

pp 790 

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into three etiological categories: idiopathic, symptomatic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.

The authorship is drawn from leading international authorities in the field providing an authoritative resource. It provides extensive coverage of the causes of epilepsy in all age groups, both common and rare, in over 100 chapters, and extensive illustrations and tables.

 

CHAPTER LIST

Foreword
Jerome Engel

Foreword
Sir John Bell

Preface
Simon Shorvon

Section 1 – Introdution
1. Historical introduction
Simon Shorvon

2. The etiological classification of epilepsy
Simon Shorvon

3. Epileptogenesis in idiopathic epilepsy
Snezana Maljevic , Holger Lerche

4. Mechanisms of epileptogenesis in symptomatic epilepsy
Mark Cook

Section 2 – Idiopathic Epilepsy
5. Introduction to the concept of genetic epilepsy
Renzo Guerrini , Simon Shorvon, Frederick Andermann, Eva Andermann

Subsection 2.1 – Pure epilepsies due to single-gene disorders
6. The genetic contribution to epilepsy: the known and missing heritability
Michael Johnson

7. Benign Familial Neonatal seizures
Perrine Plouin

8. Autosomal dominant nocturnal frontal lobe epilepsy
Paolo Tinuper, Francesca Bisulli

9. Genetic epilepsy with febrile seizures plus
Ingrid Scheffer, Yue-Hua Zhang

10. Severe myoclonic epilepsy of infancy or Dravet Syndrome
Carla Marini , Renzo Guerrini
11. Benign adult familial myoclonic epilepsy
Teiichi Onuma
Subsection 2-2 – Pure epilepsies with presumed complex inheritance
12. Idiopathic Generalised Epilepsy
Carlo Marini, Renzo Guerrini

13. Benign Partial Epilepsies of Childhood
Roberto Caraballo, Natalio Fejerman

Section 3 – Symptomatic Epilepsy
14. Introduction to the concept of symptomatic epilepsy
Simon Shorvon

Subsection 3.1 – Epilepsy Syndromes
15. West Syndrome and Lennox-Gastaut Syndrome
Renzo Guerrini, Carla Marini

Subsection 3.2 – Progressive myoclonic epilepsies
16. Unverricht-Lundborg disease
Maria Lehtinen, Anna-Elina Lehesjoki, Reetta Kalviainen

17. Dentato-rubro-pallido-luysian atrophy (DRPLA)
Teiichi Onuma

18. Lafora body disease
Anna Jansen

19. Epilepsy in mitochondrial cytopathies
Laurence Bindoff, Bernt Engelsen

20. Neuronal ceroid lipofuscinosis
Ruth Williams

21. Sialidosis and Gaucher disease
Silvana Franceschetti, Laura Canafoglia

22. Action myoclonus-renal failure syndrome
Eva Andermann

23. Progressive myoclonic epilepsies: other rarer causes
Frederick Andermann, Eva Andermann

Subsection 3.3 – Neurocutaneous syndromes
24. Tuberous Sclerosis complex
Catherine Chu-Shore, Elizabeth Thiele

25. Neurofibromatosis
Rosalie Ferner and Margaret Jackson

26. Sturge-Weber Syndrome
Alexis ArzimanoglouLeni Panagiotakaki

27. Other neurocutaneous syndromes
Ignacio Pascual-Castroviejo

Subsection 3.4 – Other single-gene disorders with epilepsy as a prominent symptom
28. Angelman syndrome
Bernard Dan, Stewart Boyd

29. Lysosomal disorders and Menkes syndrome
Edwin Kolodny, Swati Sathe

30. Neuroacanthocytosis
Anna Jansen

31. Organic acid, amino acids and peroxisomal disorders.
Maria Alice Donati, Serena Gasperini, Renzo Guerrini

32. Porphyria
Geoffrey Dean, Simon Shorvon

33. Pyridoxine-dependant epilepsy.
Sidney Gospe

34. Rett Syndrome and MECP2 and CDKL5 genotypes
Daniel Glaze

35. Urea cycle disorders
Linda Huh, Kevin Farrell

36. Wilson disease
JM Walshe

37. Disorders of cobalanin and folate metabolism
Michael Shevell, David Watkins, David Rosenblatt

38. Other single gene disorders
Vincent Navarro, Frédéric Sedel

Subsection 3.5 – Disorders of chromosome structure
39. Down syndrome.
Nadia Bahi-Buisson, Monika Eisermann, Olivier Dulac

40. Fragile X syndrome.
Irissa Devine, Carl Stafstrom

41. 4p (Wolf-Hirschhorn) syndrome
Agatino Battaglia

42. Inverted duplicated chromosome 15 (isodicentric chromosome 15)
Agatino Battaglia

43. Ring chromosome 20
Geneviève Bernard, Frederick Andermann

Subsection 3.6 – Developmental anomalies of cerebral structure (cortical dysplasia)
44. Hemimegalencephaly
M Scott Perry, Michael Duchowny

45. Focal cortical dysplasia and related variants
Ruben Kuzniecky

46. Agyria- pachygyria band spectrum
Elena Parrini, Renzo Guerrini

47. Agenesis of the corpus callosum
Dorothy Jones-Davis, Yolanda Lau, Elliott Sherr / Jones Davies

48. Polymicrogyria and schizencephaly
Renzo Guerrini, Carman Barba

49. Periventricular nodular heterotopia
Rahul Tathakrishnan, Yahya Aghakhani, François Dubeau

50. Microcephaly
Elizabeth Ross

51. Arachnoid cysts
Concezio Di Rocco, Gianpiero Tamburrini

52. Malformations of human cerebral cortex
Waney Squier

Subsection 3.7 – Hippocampal sclerosis and prenatal and perinatal injury
53. Hippocampal sclerosis
Fernando Cendes, Márcia Morita

54. Neonatal and postneonatal epilepsy – causes
Lei Mizrahi, Kevin Chapman

55. Cerebral palsy
Sameer Zuberi, Andreas Brunklaus

56. Vaccination and immunization
Simon Shorvon

Subsection 3.8 – Cerebral trauma
57. Open head injury
Flavio Giordano, Barbara Spacca, Lorenzo Genitori

58. Closed head injury
Manuel Muria-Fernandez, Jorge Borneo, Robert Teasell

59. De novo epilepsy after neurosurgery
Charles Polkey

60. Epilepsy after epilepsy surgery
Andre Palmini

61. Non-accidental braininjury
Renzo Guerrini, Alessio De Ciantis

Subsection 3.9 – Cerebral tumor
62. Glioma
William Gray, Henry Bulstrode

63. Ganglioglioma, Dysembryoplastic Neuroepithelial tumour and related tumours
Thomas Jacques, William Harkness

64. Hypothalamic hamartoma and gelastic epilepsy
John Kerrigan

65. Meningiomas
Sumeet Vadera, William Bingaman

66. Metastatic disease
Rolando Del Maestro, Abdulrahman Sabbagh, Ahmed Lary, Marie-Christine Guilot

Subsection 3.10 – Cerebral infection
67. Viral encephalitis
Jane Adcock

68. Bacterial meningitis and focal suppurative intracranial infections in children
Suresh Pujar, Richard Chin

69. Bacterial meningitis and pyogenic abscess in adults
Lina Nashef, Fahmida Chowdhury

70. Malaria
Charles Newton

71. Neurocysticercosis
Hector Garcia

72. Other Parasitic diseases
Manish Modi, Gagandeep and Singh

73. Tuberculosis
Nadir Bharucha, Roberta Raven, Vivek Nambiar

74. HIV infection
P Satischandra, S Sinha

75. Emerging and less common central nervous system viral encephalitides
HT Chong, CTTan

Subsection 3.11 – Cerebrovascular disease
76. Cerebral haemorrhage
Henry Dinsdale

77. Cerebral infarction and occult degenerative cerebrovascular disease
Ruth Namire, R Eugene Ramsey

78. Arteriovenous malformations
SA Tharin, Autumn Klein, Robert Friedlander

79. Cavernous maalformations
Adrian Siegel

80. Other vascular disorders
Leif Gjerstad, Erik Taubøll

Subsection 3.12 – Cerebal immunological disorders
81. Rasmussen encephalitis and related conditions
Antonio Gambardella, Frederick Andermann

82. Systemic lupus erythematosus and other collagen vascular diseases
Rolando Cimaz, Andrea Taddio

83. Inflammatory and immunological diseases of the central nervous system
Michael Lunn

Subsection 3.13 – Other cerebral disorders
84. Psychiatric disorders
Brent Elliott, John O’Donavan

85. Mutiple sclerosis and other acquired demyelinating diseases
Mark Manford

86. Hydrocephalus, porencephaly
Pierangelo Veggiotti, Frederica Teutonico

87. Alzheimer disease and other adult degenerative disorders
Sigmund Jenssen, Kandan Kulanfaivel

Section 4 – Provoked Epilepsies
88. Introduction to the concept of provoked epilepsy
Simon Shorvon, Renzo Guerrini, Frederick Andermann

Subsection 4.1 Precipitating factors
89. Fever
Thomas Bleck

90. The menstrual cycle and catamenial epilepsy
Andrew Herzog

91. Sleep
Liborio Parrino, Giulia Milioli, Fernado De Paolis, Andrea Grassi, Gioia Gioi, Mario Giovanni Terzano

92. Metabolic and endocrine-induced seizures
Bernhard Steinhoff

93. Electrolyte or sugar disturbances
Bindu Menon, Simon Shorvon

94. Drug-induced seizures
Aidan Neligan

95. Alcohol and toxin-induced seizures
Michelle Shapiro, Andrew Cole

Subsection 4.2 – Reflex seizures
96. How reflex mechanisms cause epilepsy
Benjamin Zifkin, Frederick Andermann

97. Visual stimuli, photosensitivity and photosensitive epilepsy
Dorothée KAsteleijn-Nolst Trenité, Laura Cantonetti, Pasquale Parisi

98. Startle-induced (and other sensory induced) epilepsy
Jean-Pierre Vignal , Andrine Aubert, Patrick Chauvel

99. Primary reading epilepsy
Matthias Koepp

100. Auditory-induced epilepsy
Carlo Di Bonaventura, Frederick Andermann

101. Focal reflex seizures – with emphasis on epilepsy triggered by eating
Benjamin Zifkin, Guy Rémillard, Frederick Andermann

102. Hot water epilepsy
P Satischandra, S Sinha, Anuranjan Anand

103. Reflex epilepsy with higher-level processing
Benjamin Zifkin, Frederick Andermann

Section 5 – Status Epilepticus
104. Introduction – how status epilepticus is caused
Karthik Rajasekaran, Howard Goodkin

105. Causes of status epilepticus in children
Rodd Scott

106. The causes of convulsive status epilepticus in adults
Elizabeth Waterhouse, Peter Kaplan

107. Uncommon causes of status epilepticus
Simon Shorvon, Raymond Tan, Aidan Neilgan

108. Causes of non-convulsive status epilepticus in adults
Pierre Thomas

109. Causes of epilepsia partialis continua
Hirokazu Oguni and Frederick Andermann

100. Afterword
Simon Shorvon, Renzo Guerrini, Frederick Andermann

Author: Simon Shorvon 

Publisher: Wiley-Blackwell 

1200 pages

 

The Handbook of Epilepsy Treatment is a monograph on the treatment of epilepsy. It is a practical but comprehensive coverage of medical and surgical treatment with extensive tables and summaries, designed for trainees and specialists. The Handbook of Epilepsy Treatment covers:

Treatment of the different forms and causes of epilepsy
Treatment in the different commonly encountered clinical situations
Treatment in children, in adults, in the elderly, in women, in epilepsy syndromes and in those with special needs and requirements
Epilepsy drugs – their pharmacology, kinetics, side effects, effectiveness and practical usage in the clinic
Epilepsy surgery – the various types, the indications, assessment and outcome
A pharmacopeia summarizes the entire range of anti-epileptic medications with emphasis on effective prescribing in the clinical setting.

 

TABLE OF CONTENTS

Chapter 1 Definitions and Epidemiology.
Definitions
Frequency and population features of epilepsy

Chapter 2. Seizure Type and Anatomical Location of Seizures.
Seizure type.
Classification of partial seizures by anatomical site of seizure onset.

Chapter 3. Epilepsy Syndromes.
ILAE Classification of the Epilepsies and Epilepsy Syndromes.
The epilepsy syndromes.

Chapter 4. The Causes of Epilepsy.
Idiopathic epilepsy.
Symptomatic epilepsy of genetic or congenital origin.
Symptomatic epilepsy due to acquired causes.
Provoked seizures.

Chapter 5. Principles of Treatment.
Why treat epilepsy? The aims of treatment.
The risks of epilepsy and its treatment.
Choice of antiepileptic drug therapy based on seizure type.
Treatment of specific epilepsy syndromes.
Principles of treatment of newly diagnosed patients.
Principles of treatment of patients with established active epilepsy.
Treatment of patients with epilepsy in remission.
Psychiatric disorders in epilepsy.
Life-threatening idiosyncratic reactions.
Complementary and alternative therapy in epilepsy.
Genetic counselling in epilepsy.

Chapter 6. Treatment of Epilepsy in Specific Groups.
Treatment of epilepsy in children.
Treatment of epilepsy in patients with additional handicaps.
Epilepsy in elderly people.
Treatment of epilepsy in women.

Chapter 7. Pharmacokinetic Principles of Antiepileptic Drug Treatment.
Drug absorption.
Drug distribution.
Drug elimination (metabolism and excretion).
Blood level measurements.

Chapter 8. The Antiepileptic Drugs.
Carbamazepine.
Clobazam.
Clonazepam.
Eslicarbazepine acetate.
Ethosuximide.
Gabapentin.
Lacosamide.
Lamotrigine.
Levetiracetam.
Oxcarbazepine.
Phenobarbital.
Phenytoin.
Pregabalin.
Primidone.
Rufinamide.
Tiagabine.
Topiramate.
Valproate.
Vigabatrin.
Zonisamide.
Other drugs used in the treatment of epilepsy.
– Acetazolamide.
– Benzodiazepines.
– Corticosteroids and ACTH.
– Felbamate.
– Piracetam.
– Stiripentol.

Chapter 9. The Emergency Treatment of Epilepsy.
How to deal with a seizure.
Status epilepticus.
Antiepileptic drugs used in status epilepticus.

Chapter 10. The Surgical Therapy of Epilepsy.
Presurgical assessment – general points.
Surgery in epilepsy arising in the mesial temporal lobe.
Surgery in epilepsy arising in extratemporal regions and the temporal neocortex.
Cortical dysplasia (malformations of cortical development).
Surgery where no lesion is apparent on neuroimaging (‘MRI-negative cases’)
Hemispherectomy, hemispherotomy and other large resections.
Corpus callosectomy (corpus callosum section, corpus callosotomy).
Multiple subpial transection.
Vagal nerve stimulation.
Other functional surgical procedures.
The organization of epilepsy surgery care: the epilepsy surgery centre.
Pharmacopoeia.
Antiepileptic drugs – indications in epilepsy.
Antiepileptic drugs – dose, average adult values.
Antiepileptic drugs – dose, interactions.
Antiepileptic drugs – dose, in children.
Antiepileptic drugs – summary of side effects.
Antiepileptic drugs – summary of metabolism.
Antiepileptic drugs – summary of pharmacokinetic values (typical adult values).
Antiepileptic drugs – modes of action.

Further Reading.

Simon Shorvon 
Oxford University Press, Oxford. 2009. | ISBN 978-0-19-957692-0 |pp. 172

This book is part of the Oxford Neurology Library. It aims to be a concise pocketbook for the practicing clinician. The purpose of the book volume is to provide a short but comprehensive survey of epilepsy and its management for the busy clinician. It is very definitely intended to be a clinical tool—and what is provided is clinical information rather than data relevant to research or experimental study. Factual information is contained as much as possible, in a digestible form, and to avoid longwinded or complex description. Diagnosis, treatment and counselling are especially emphasized, for it is in these areas that accurate data and clinical skill are particularly needed. Pharmacological, pharmacokinetic and therapeutic details of individual drugs are summarized in tables for rapid reference. Emergency and surgical therapies for epilepsy are also covered. The book is designed for generalists, specialists and trainees.

 

TABLE OF CONTENTS

Preface vi
Symbols and abbreviations vii
1.Definition and frequency of epilepsy 1
2. Clinical forms of epilepsy 7
3. The causes of epilepsy 29
4. The differential diagnosis and investigation of epilepsy 49
5. Principles of treatment of epilepsy 65
6.Anti-epileptic drugs 91
7. Epilepsy surgery 123
8. Emergency treatment of epileptic seizures 139
9. Social and psychosocial aspects of epilepsy 153
Index 167

Edited by Simon Shorvon and Timothy A. Pedley 
Saunders, Philadelphia, 2009. 
355 pages 38 ills | Trim size 6 X 9 in | ISBN: 1405131349

This title in the Blue Books of Neurology series highlights advances in epileptology and new ways of managing seizure disorders. Contributors from around the world lend a global perspective. The chapters are focused on areas in which there are significant new findings or those that are controversial. Basic research and clinical topics are included. There are detailed discussions of difficulties in diagnosing and treating epilepsy, including the latest pharmacologic management strategies.

TABLE OF CONTENTS

1. Seizure Prediction: Its Evolution and Therapeutic Potential. pp1-16
David Kreiger and Brian Litt

2. Febrile Seizures. pp 17-26
Celine M Dube and Tallie Z Baram
3. Mechanisms of Action of Levetiracetam and Newer SV2A Ligands. pp 27-38
Henrik Klitgaard and Alain Matagne

4. Long-Term Effects of Seizures on Brain Structure and Function. pp 39-52
Howard F Goodkin and Edward H Bertram

5. Dipole Source Modeling in Epilepsy: Contribution to Clinical Management. pp 53-64
John S Ebersole

6. EEG-correlated fMRI in Epilepsy: current state of the art. pp 65-83
Rachel Thornton and Louis Lemieux

7. Epilepsy and Sleep. pp 84-96
Soheyl Noachtar and Jan Remi

8. Cortical Myoclonus and Epilepsy: Overlap and Differences. pp 97-118
Renzo Guerrini and Francesco Mari

9. The Life-Threatening Epilepsies of Childhood and Their Treatment. pp 119-128
Catherine Chiron

10. The Spectrum of Epilepsies Associated with Generalized Spike and Wave Patterns. pp 129-144
Michael Koutroumanidas and Chrysostomos Panayiotopoulos

11. Epilepsies due to Monogenic Disorders of Metabolism. pp 145- 160
Chantal Depondt

12. Rasmussen’s Encephalitis. pp 161-176
Tiziana Granata and Carlo Antozzi

13. Seizures and Epilepsy in the Elderly. pp 177-193
Ann Mendiratta and Timothy Pedley

14. Psychosis of Epilepsy. pp 194-210
Andres M Kanner

15. Sudden Unexpected Death in Epilepsy. pp 211-240
Fergus Rugg-Gunn and Lina Nashef

16. The Management of Epilepsy in Pregnancy. pp 241-264
Torbjorn Tomson and Dina Battino

17. Does Early Treatment Influence the Long-Term Outcome of Epilepsy. pp 265-276
Anthony Marson

18. Pharmacodynamic Interactions of Antiepileptic Drugs. pp 277-293
Gail D Anderson and Jong M Rho

19. The Surgery of Temporal Lobe Epilepsy I – Historical Development, Patient Selection, and Seizure Outcome. pp 294-306
Nicholas Moran and Simon Shorvon

20. The Surgery of Temporal Lobe Epilepsy II – Surgical Complications and Long-Term Adverse Effects. pp 307-321
Simon Shorvon and Nicholas Moran

21. Brain Stimulation in Epilepsy – An Old Technique with a New Promise? pp 322-241
Kristl Vonck and Paul Boon

Simon Shorvon, Giselle Weiss, Giuliano Avanzini, Jerome Engel, Harry Meinardi, Solomon Moshe, Edward Reynolds, Peter Wolf. 
Wiley-Blackwell, 2009. | pp. 338. | ISBN 9781405 1895520

The International League Against Epilepsy (the ILAE) was founded on August 30th 1909, and is one of the oldest international subspecialist organisations in medicine. This book is published to mark its centenary, with the aims of documenting its course over its first 100 years, of interpreting its activities within their historical context, and of assembling source material.

The book is the result of a large amount of original research from published and unpublished written material and from the verbal recollections and experiences of individuals within the organisation. The text attempts to provide a scholarly, lively and instructive history, which is the definitive account of an organisation whose goal throughout its 100 year history has been to work towards the alleviation of the suffering caused by epilepsy around the world.

The authors of this book have held various positions on the ILAE executive. Giuliano Avanzini and Jerome Engel have each served both as Treasurer and President of the ILAE; Harry Meinardi was previously ILAE Secretary-General and President; Solomon Moshé is currently Secretary-General and President-elect of the ILAE; Edward Reynolds was a previous ILAE President; Peter Wolf is currently President and has been Secretary General of the ILAE; Simon Shorvon serves currently as co-Editor-in-Chief of Epilepsia and was previously ILAE Information Officer and Vice- President. Giselle Weis is the Centenary Archivist of the League.

 

TABLE OF CONTENTS

Preface, viii – xix
Simon Shorvon

Introduction, x-xiv
Simon Shorvon

1. International League Against Epilepsy – the first period: 1909–1952, 1
Simon Shorvon and Giselle Weiss

2. International League Against Epilepsy – the second period: 1953–1992. pp 45 – 98
Giselle Weiss and Simon Shorvon

3. International League Against Epilepsy – the third period: 1993– 2009. pp 97 – 130
Giuliano Avanzini, Jerome Engel, Jr., Edward Reynolds, Simon Shorvon,Giselle Weiss and Peter Wolf

4. Development of the classification and nosology of epilepsy 1909–2009, pp 131 – 142
Peter Wolf

5. Organisation of basic science in epilepsy with special reference to the International League Against Epilepsy, pp 143 – 152
Jerome Engel, Jr., Solomon Moshé and Giuliano Avanzini

6.The relations of the International League Against Epilepsy with the lay organisations, pp 153 – 162
Harry Meinardi

7. Epilepsia – the journal of the International League Against Epilepsy, pp 163 – 206
Simon Shorvon

8. International League Against Epilepsy – commissions, task forces and the Global Campaign Against Epilepsy, pp 207 – 215
Peter Wolf and Edward Reynolds

9. International League Against Epilepsy – the international symposia and congresses, 1909–2009, p 216 – 254
Giselle Weiss and Simon Shorvon

Appendices
Appendix 1 ILAE Chapters and dates of incorporation, 255
Appendix 2 ILAE Executive Committee membership, 259
Appendix 3 ILAE Commission membership, 263
Appendix 4 ILAE Financial statements, 273
Appendix 5 ILAE Constitutions and Bylaws, 289
Appendix 6 ILAE Ambassadors for Epilepsy, 1968–present, 309
Giselle Weiss

Eds: Clarke C, Howard R, Shorvon S, Rossor M 
Wiley-Blackwell, Oxford. 
991 Pages | ISBN-10: 1-4051-3443-7 | ISBN-13: 978-1-4051-3443-9

This is a textbook of neurology from the UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery at Queen Square, London, and content based on the neurological training programme.

The book attempts to blend clinical and basic neuroscience, particularly in relation to molecular biology, genetics, neurochemistry and physiology. The book presents a synthesis of modern science with traditional clinical neurology rooted in history taking and the meticulous elicitation of physical signs.

 

TABLE OF CONTENTS

1. Neurology Worldwide: the Burden of Neurological Disease. pp 1 – 12
Simon Shorvon

2. Nervous System Structure and Function. pp 13 – 74
Charles Clarke and Roger Lemon

3. The Language of Neurology: Symptoms, Signs and Basic Investigations. pp 75 – 108
Charles Clarke, Richard Fracknowiak, Robin Howard, Martin Rossor and Simon Shorvon

4. Stroke and Cerebrovascular Diseases. pp 109 – 154
Nicholas Lossef, Martin Brown and Joan Grieve

5. Movement Disorders. pp 155 – 189
Niall Quinn, Kailash Bhatia, Peter Brown, Carla Cordivari, MArwan Hariz, Andrew Lees, Patricia Limousin, Mary Robertson, Anette Schrag, Sarah Tabrizi

6. Epilepsy and Related Disorders. pp 198 – 244
Simon Shorvon, John Duncan, Mathias Koepp, Josemir Sander, Shelagh Smith, Matthew Walker

7. Cognitive Impairment and Dementia. pp 245 – 288
Martin Rossor, John Collinge, Nick Foz, Robin Howard, Giovanni Mallucci, Catherine Mummery, Jason Warren

8. Infection in the Nervous System. pp 289 – 336
Robin Howard and Hadi Manji

9. Nerve and Muscle Disease. pp 227 – 410
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Mary Reilly

10. Multiple Sclerosis and Demyelinating Diseases. pp 411 – 448
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller, Alan Thompson

11. Headache. pp 449 – 464
Peter Goadsby

12. Cranial Nerve Disorders. pp 465 – 488
Paul jarman, Jeremy Chataway, Charles Clarke, Robin Howard

13. Neuro-ophthalmology. pp 489 – 532
Gordon Plant, James Acheson, Charles Clarke, Elizabeth Graham, Robin Howard, Simon Shorvon

14. Neuro-otology. pp 533 – 584
Rosalyn Davies, Linda Luxon, Doris-Eva Bamiou, Simon Shorvon

15. Spinal Cord Disorders. pp 585 – 628
Simon Farmer, Adrian Casey, David Choi, Robin Howard, Geoffrey Raisman

16. Cerebellar Ataxias and Related Conditions. pp 629 – 644
Nicholas Wood

17. Restorative and rehabilitation neurology. pp 645 – 676
Richard Greenwood, Jan Marsden, Diane Playford, Valerie Stevenson, Nick Ward

18. Toxic, Metabolic and Physical Insults to the Nervous System and inborn errors of metabolism. pp 675 – 722
Robin Howard, Robin Lachmann, Philip Lee, Alexander Leff

19. Disorders of Consciousness, Intensive Care Neurology and Sleep. pp 723 – 770
Robin Howard, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Matthew Walker

20. Neuro-oncology. pp 771 – 822
Jeremy Rees, Sebastian Brandner, Robin Howard, Rolf Jager, Susan Short, David Thomas, Emma Townsley, Gelareh Zadeh

21. Psychiatry and Neurology. pp 823-846
Michael Trimble

22. Pain. pp 847 – 870
Geoffrey Schott

23. Autonomic Dysfunction. pp 871 – 892
Christopher Matthias

24. Uro-neurology. pp 893 – 912
Clare Fowler, Sohier Elneil

25. Systemic Conditions and Neurology. pp 913 – 944
David Werring, Robin Howard, Alexander Leff, Simon Shorvon

Dr Matthew Walker & Professor Simon Shorvon

‘Understanding Epilepsy’ is an illustrated guide which aims to clear and concise information and advice for patients, their families and friends and the lay public. The contents include:

Diagnosis of epilepsy and the different types of epileptic seizures
Investigations carried out and the causes of epilepsy
Medical and surgical treatment of epilepsy
Lifestyle and selfhelp guidelines
Social issues
Useful addresses and websites
Glossary of terms
The book is part of a series produced by the British Medical Association in association family Doctor Publications. Its usual retail cost is £4.75

New edition published 2009.

Simon Shorvon
ISBN: 1405131349 | August 2005 | 292 pages | UK £41.50 | US $69.95 | AUS $130.00

The Handbook of Epilepsy Treatment: forms, causes and therapy in children and adults provides a comprehensive coverage of medical and surgical therapy. It includes sections on: all current antiepileptic drugs; drug choice; pharmacokinetics; various surgical approaches; complementary and alternative therapies; emergency treatment of seizures and of status epilepticus; the treatment of psychiatric disorders associated with epilepsy; genetic counselling.

There are practical guides for the treatment of patients with newly diagnosed epilepsy, chronic epilepsy and epilepsy in remission, and sections on therapy in different epilepsy types and syndromes and in different patient groups such as children, women and elderly. The book also has also an opening chapter on the clinical forms and causes of epilepsy, and throughout the text new information is incorporated, particularly from the rapidly advancing fields of clinical genetics and clinical pharmacology.

The Handbook of Epilepsy Treatment: forms, causes and therapy in children and adults aids the doctor in the day-to-day management of the patient with epilepsy. It provides enough detail to be useful as a reference and yet gives information in an easy-to-use format for busy clinical practice. This concise and readable book is an invaluable guide for all doctors, regardless of specialty, seeing patients. A new pharmacopoeia is appended for quick reference and there are approximately 200 tables/figures/summary tables to assist clarity.

CONTENTS

1: The clinical forms and causes of epilepsy
Epilepsy
ILAE classification of seizure type
ILAE classification on the epilepsies and epilepsy syndromes
Classification of partial seizures by anatomical site of seizure onset
The age-related epilepsy syndromes
The causes of epilepsy
Epilepsy due to genetic or developmental causes
Epilepsy due to acquired causes
Seizure precipitants
The reflex epilepsies
Acute symptomatic seizures

2: The principles of drug treatment

Why treat epilepsy?
Pharmacokinetic principles of antiepileptic drug treatment
Choice of drugs for different seizure types
Treatment of specific epilepsy syndromes
Principles of treatment of newly diagnosed patients
Principles of treatment of patients with established active epilepsy
Treatment of patients with epilepsy in remission
Treatment of epilepsy in children
The treatment of epilepsy in the elderly
The treatment of epilepsy in women
The treatment of psychiatric disorders in epilepsy
Complementary and alternative therapy in epilepsy
Genetic counselling in epilepsy

3: The antiepileptic drugs

Carbamazepine
Clobazam
Clonazepam
Ethosuximide
Gabapentin
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenobarbital
Phenytoin
Pregabalin
Primidone
Tiagabine
Topiramate
Valproate
Vigabatrin
Zonisamide
Other drugs used in the treatment of epilepsy:
Acetazolamide
BenzodiazepinesDiazepam
Clorazepate
Nitrazepam
Corticosteroids and adrenocorticotropic hormone (ACTH)
Felbamate
Mesuximide
Piracetam
Rufinamide

4: The emergency treatment of epilepsy

The immediate management of a seizure
Status epilepticus
Antiepileptic drugs used in status epilepticus

5: The surgical treatment of epilepsy

Introduction
Pre-surgical assessment — general points
Surgery in epilepsy arising in the mesial temporal lobe
Surgery in epilepsy arising in extra-temporal regions and in the temporal neocortex
Surgery where no lesion is apparent on neuroimaging
Hemispherectomy, hemispherotomy and other large resections
Corpus callosectomy (corpus callosum section, corpus callosotomy)
Multiple subpial transection
Vagus nerve stimulation
Other functional surgical procedures
The organization of epilepsy surgery care: the epilepsy surgery centre

Pharmacopoeia

Simon Shorvon, Institute of Neurology, UCL, London, UK Emilio Perucca, University of Pavia, Pavia, Italy
David Fish, Institute of Neurology, UCL, London, UK
W Dodson, Washington University School of Medicine, St Louis, MO, USA

ISBN 0632060468 Illustrated Hardback, $225.00

JANUARY 2004, 992 pages

Epilepsy is a common and important neurological condition, and its treatment has become increasingly complex in recent years. In contrast to many existing large volumes on epilepsy, where the coverage of biology and phenomenology of the condition dominates, this textbook concentrates on the clinical treatment and day-to-day management of epilepsy. The first edition was published in 1996 and has become a standard text in the field. Since then, the science of epilepsy has advanced remarkably, and this second edition has been fully revised to reflect these advances as they relate to treatment, with 28 new chapters, 108 contributors and two new editors.

The primary purpose of the book has however not changed. As before it is to provide a systematic survey of the whole field of contemporary treatment. Medical and surgical therapies are both covered in depth, as are the principles of treatment in different clinical contexts. A deliberately international perspective is taken, and account taken of the changing social and cultural aspects of modern epilepsy practice.

The book is a reference work with a strong practical bias, aiming to guide clinical practice and rational therapy in sometimes difficult decisions involved in successful therapy. This definitive text is a source of reference and assistance for neurologists and neurosurgeons, other clinicians and trainees at all levels who treat patients with epilepsy.

From reviews of the 2nd edition

“The second edition of The Treament of Epilepsy is a vital contribution to the field … The book is highly recommended for anybody who is involed in the ecaluation and medical care of patients with epilepsy.”
Lancet

From reviews of the 1st edition

“The four distinguished editors … deserve to be warmly congratulated on the production of this book … highly recommended … beautifully printed. It is a major contribution to the literature on epilepsy.”
Brain

“I recommend this book. I think it is a splendid achievement and I congratulate the authors, the editors and the publishers.”
British Journal of Neurosurgery

“This book can be recommended to each neurologist, neurosurgeon or physician interested in epilepsy.”
European Neurology

“A ‘must read’ for neurologists in training.”
British Medical Journal

“The book appeals because it combines authority with a style which demonstrates the seriousness with which the editors (and their contributors) have sought to bring epilepsy into the full focus of late-twentieth century clinical neuroscience, and their efforts have been outstandingly successful … This is a fine book written by the experts for those who treat epilepsy.”
Lancet

“Over 800 pages, 63 chapters and over 80 contributors, all of outstanding international status, makes this the definitive book on the subject.”
Journal of Neurological Sciences

Simon Shorvon, Emilio Perucca, Jerome Engel (Editors) 
Wiley-Blackwell, Oxford (2009). | ISBN 978-1-4051-8383-3 | pp 1200

This is a textbook of epilepsy treatment, in its third edition and considered a standard reference work worldwide. Its primary objective is to provide a systematic review of the whole field of contemporary therapy in epilepsy. The emphasis is, as before, on a text that provides practical information, useful for the clinician but which is comprehensive, accurate and concisely given. The basic purpose of the book to guide clinical practice and rational therapy, and to be a source of reference for clinicians at every level.

The book has a new editor and has increased in size from 63 in the first edition, to 74 in the second and to 85 in this edition. There are 26 completely new chapters, as well as extensive updating of the others. There are 90 new authors, joining the 53 who contributed to both this and the previous edition. The new chapters reflect the significant changes which have been made to the principles of, and approaches to, epilepsy therapy, the introduction of new drugs and the development of new surgical techniques.

The three editors are, or have been, long-standing members of the ILAE executive and almost all of the lead authors of the chapters of our book are involved deeply in the league. Indeed, contributors to the book are from 17 countries in all five continents, reflecting the global reach.

In the historical introduction to this edition, the historical survey of drug therapy in epilepsy is continued, bringing this up to the year 1989. In the previous two editions, the survey covered the years 1857– 1938 and then 1938–1955. Here, the story is advanced by 35 important years to 1989, and is written from the particular perspective of the ILAE.

TABLE OF CONTENTS

Forword, xv
Preface to the Third Edition, xvii
Historical introduction: History of the Drug Treatment of Epilepsy Between 1955 and 1989 with Special Reference to the Role of the International League Against Epilepsy (ILAE), xxi
Simon Shorvon

Section 1 – Introdution
1. Definitions and Classification of Epilepsy, 3 1
Christina A. Gurnett and W. Edwin Dodson

2. Epidemiology and Prognosis of Epilepsy, 21
Lars Forsgren and Dale Hesdorffer

3. Aetiology of Epilepsy, 33
Simon D. Shorvon

4.Differential Diagnosis of Epilepsy, 55
Mark Cook

5. Mechanisms of Epileptogenesis, 67
Giuliano Avanzini and Silvana Franceschetti

6.Antiepileptic Drug Discovery, 81
H. Steve White

7. Mechanisms of Antiepileptic Drug Action, 91
Matthew C. Walker, Rainer Surges and Andrew Fisher

8. Mechanisms of Tolerance and Drug Resistance, 109
Wolfgang Löscher and Dieter Schmidt

Section 2 – Principles of Medical Management
9. General Principles of Medical Management, 121
Emilio Perucca

10 Management of Newly Diagnosed Epilepsy, 141
Yvonne M. Hart

11 Management of Chronic Active Epilepsy in Adults, 153
Simon D. Shorvon

12 Management of Epilepsy in Remission, 163
Patrick Kwan and Howan Leung

13 Management of Epilepsy in Infants, 171
Catherine Chiron

14 Management of Childhood Epilepsy Syndromes, 179
Colin D. Ferrie

15 Management of Epilepsies Associated with Specific Diseases in Children, 195
John H. Livingston

16 Management of Epilepsy in the Elderly, 203
Hiba Arif, Anil Mendiratta and Lawrence J. Hirsch

17 Management of Epilepsy in People with Learning Disabilities, 219
Eylert Brodtkorb

18 Emergency Treatment of Seizures and Status Epilepticus, 231
Matthew C. Walker and Simon D. Shorvon

19 Traumatic Brain Injury and Other Risks, 249
Marc Dichter and Nancy R. Temkin

20 Management of Medical Co-morbidity Associated with Epilepsy, 259
Gagandeep Singh

21 Psychiatric Features of Epilepsy and their
Brent Elliott, Meriem Amarouche and Simon D. Shorvon

22 Management of Side-effects of Antiepileptic Drugs, 28
Gaetano Zaccara, Fabrizio Balestrieri and Aldo Ragazzoni

23 Ketogenic Diets, 301
Eric H. Kossoff and Jennifer L. Dorward

24 Non-pharmacological, Complementary and Alternative Treatments for Epilepsy, 311
Tom Whitmarsh

25 Reproductive Aspects of Epilepsy Treatment, 323
Torbjörn Tomson

26 Epilepsy Counselling, 335
Anthony Linklater, Doreen Patsika and Susan Usiskin

27 Genetic Counselling in Epilepsy, 341
Federico Zara

28 Drug Interactions, 361
Edoardo Spina

29 Medical Treatment of Epilepsy in Situations with Limited Resources, 379
Gretchen L. Birbeck

Section 3 – Antiepileptic Drugs
30 Introduction to the Choice of Antiepileptic Drugs, 389
Emilio Perucca

31 Acetazolamide, 399
Miri Y. Neufeld

32 Adrenocorticotropic Hormone and Corticosteroids, 411
Federico Vigevano and Maria Roberta Cilio

33. Benzodiazepines used Primarily for Chronic Treatment (Clobazam, Clonazepam, Clorazepate and Nitrazepam), 459
Peter Camfield and Carol Camfield

34 Benzodiazepines used Primarily for Emergency Treatment (Diazepam, Lorazepam and Midazolam), 469
Eugen Trinka

35 Brivaracetam, 421
Philipp von Rosenstiel and Emilio Perucca

36 Carbamazepine, 443
Matti Sillanpää, Leena Haataja, Torbjörn Tomson and Svein I. Johannessen

37 Carisbamate, 433
Gerald P. Novak and Martin J. Brodie

38 Eslicarbazepine Acetate, 485
Luis Almeida, Meir Bialer and Patricio Soares-da-Silva

39 Ethosuximide, 499
Tracy A. Glauser and Emilio Perucca

40 Felbamate, 511
Ilo E. Leppik and James R. White

41 Gabapentin, 519
Ernest R. Somerville and Andrew W. Michell

42 Lacosamide, 527
Rajesh Sachdeo

43 Lamotrigine, 535
Fumisuke Matsuo and Awais Riaz

44 Levetiracetam, 559
Jacqueline A. French and Françoise Tonner

45 Oxcarbazepine, 575
Edward Faught and Nita Limdi

46 Phenobarbital, Primidone and Other Barbiturates, 585
Roberto Michelucci, Elena Pasini and Carlo Alberto Tassinari

47 Phenytoin, 605
Mervyn J. Eadie

48 Piracetam, 619
Simon D. Shorvon

49 Pregabalin, 627
Sylvain Rheims and Philippe Ryvlin

50 Retigabine, 637
Harry Mansbach and Michel Baulac

51 Rufinamide, 647
Victor Biton

52 Stiripentol, 657
Kai Eriksson and Tapani Keränen

53 Tiagabine, 663
Reetta Kälviäinen

54 Topiramate, 673
J. Helen Cross and Catherine J. Riney

55 Valproate, 685
Blaise F.D. Bourgeois

56 Vigabatrin, 699
Günter Krämer and Gabriele Wohlrab

57 Zonisamide, 713
Stephen J. Wroe

58 Other Drugs Rarely Used, 721
Hartmut Meierkord and Martin Holtkamp

59 Antiepileptic Drugs in Early Clinical Development, 733
Philip N. Patsalos and Josemir W. Sander

Section 4 – Presurgical Assessment and Epilepsy Surgery
60 Overview of Surgical Treatment for Epilepsy, 743
Jerome Engel Jr

61 Scalp EEG in the Epilepsy Surgery Evaluation, 757
Christine Bower Baca and John M. Stern

62 Invasive EEG in Presurgical Evaluation of Epilepsy, 767
Susan S. Spencer, Dang K. Nguyen and Robert B. Duckrow

63 MEG in Presurgical Evaluation of Epilepsy, 799
Hermann Stefan, Stefan Rampp and Rüdiger Hopfengärtner

64 MRI in the Presurgical Evaluation, 805
Jörg Wellmer and Christian E. Elger

65 PET and SPECT in Presurgical Evaluation of Epilepsy, 821
Wim Van Paesschen, Karolien Goffin and Koen Van Laere

66 Experimental Neurophysiological Techniques, 829
François Mauguière, Isabelle Merlet and Julien Jung

67 Neuropsychological Testing in Presurgical Evaluation, 851
Marilyn Jones-Gotman and Jelena Djordjevic

68 Presurgical Psychiatric Evaluation, 865
Andres M. Kanner

69 Mesial Temporal Lobe Surgery and Other Lobar Resections, 875
James Leiphart and Itzhak Fried

70 Resective Surgery of Neoplasms, 887
Nicholas Wetjen, Mithri R. Junna, Kurupath Radhakrishnan, Aaron Cohen-Gadol and Gregory D. Cascino

71 Resective Surgery of Vascular and Infective Lesions for Epilepsy, 903
Christopher E. Uff and Neil D. Kitchen

72 Surgery of Developmental Anomalies Causing Epilepsy, 925
Joshua Chern and Youssef G. Comair

73 Hemispherectomy for Epilepsy, 935
Georg Dorfmüller, Christine Bulteau and Olivier Delalande

74 Corpus Callosotomy, 943
David W. Roberts

75 Hypothalamic Hamartoma and Multiple Subpial Transection, 951
Michael C. Smith, Richard Byrne and Andres M. Kanner

76 Awake Surgery for Epilepsy, 959
Christian B. Kaufman and Webster H. Pilcher

77 Epilepsy Surgery in Children, 967
Jason S. Hauptman and Gary W. Mathern

78 Stereotactic Surgery for Epilepsy, 975
Andrew W. McEvoy and Fiona J.L. Arnold

79 Complications of Epilepsy Surgery, 993
Charles E. Polkey

80 Anaesthesia for Epilepsy Surgery, 1007
Barbara Van de Wiele

81 Vagal Nerve Stimulation, 1017
Steven C. Schachter

82 Brain Stimulation, 1025
Gregory K. Bergey

83 Stereotactic Radiosurgery for Medically Intractable Epilepsy, 1035
Isaac Yang, Edward F. Chang and Nicholas M. Barbaro

84 Future Focal Treatment Approaches to Epilepsy, 1043
Hannah R. Cock and Karen E. Nilsen

85 Epilepsy Surgery in Countries with Limited Resources, 1051
Andre Palmini

Index, 1057