Simon Shorvon
Cambridge University Press
Pages: 760, i-x
ISBN 9781108842617 (Hardback)

Epilepsy has a fascinating history. To the medical historian Oswei Temkin it was ‘the paradigm of the suffering of both body and soul in disease’. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 1860–2020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and when societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.

• The definitive text on the history of epilepsy in the twentieth century
• Tackles the subject on a broad front – incorporating not only the medical features of epilepsy, but also the important scientific, societal and personal aspects
• Details the key episodes and paradigm shifts in the history of epilepsy to clearly show the direction of travel of epilepsy
• Covers those elements in history which have endured and those which have not, critically examining the theories and practices from the vantage point of the present day

Table of Contents

Preface

Part I. The Voyage of the Good Ship Epilepsy:
Introduction
Prologue: a note on the concept of epilepsy

Part II. ‘A Plague Upon Your Epileptic Visage’:
1. 1860–1914 the birth of modern epilepsy
2. 1914–1945 epilepsy in the age of catastrophe
3. 1945–1970 epilepsy and the new world order
4. 1970–1995 epilepsy in a globalised world
5. 1995–2020 the epilepsy floods are too recent

Part 3. Epilepsy – the paradigm of the suffering of both body and soul in disease:
Epilogue – The separation of the wheat from the chaff
Appendix 1. ‘The epilepsy balance sheet’
Appendix 2. Obsolete or failed theories and treatments
Appendix 3. The international league against epilepsy

Glossary of scientific and medical terms in the field of epilepsy

Index of names

Bibliography.

 

Book Reviews

• Epigraph
• Brain
• Epilepsia Open
• Journal of the History of the Neurosciences
• World Neurology

Simon Shorvon. Old School Press. 2023.
Pages 197 ISBN 978 1 899933 48 8

Susan Allix has been making Fine Press Artist’s books for fifty years and in this time has produced seventy-seven titles, as well as nine children’s books and special bindings for thirty-eight other books. A graduate of the Royal College of Art and a recipient of the Prix de Rome, she has been called ‘the greatest bookmaker of her generation’ – a claim that calls for this timely authoritative work on Allix and her books. On Books is a detailed appreciation of her output, background to her life and training, coverage of her collectors, booksellers, and auctions, and a list of ninety-nine public collections around the world that hold her work. The second part of the books is a fifty-page comprehensive catalogue raisonné of her entire output/

Allix is unique in creating her books in their entirety. She designs and prints all the images by hand, prints all her text by letterpress, binds her books often in complex and spectacular leather designs, mixes her own pigments, writes some of the text, has created several new letterforms, and on occasions has included her own hand-made papers. Her intaglio and relief images are made with a startling variety of techniques, often in complex combinations in one image. Her bindings frequently involve different types of leather and paper with superimposed silver, other metals, and found objects. She uses many decorative and printing papers in her books. She is a colourist creating colours of deep intensity and feeling. The themes of her books include the relationship of time and space, travel, the cycles of nature and transience of beauty, and the ancient world. Some texts are literary and scholarly, with a penchant for the antique, the orient and the classical, architecture, and poetry.

The text of On Books has been set in Monotype Dante and Optima on a generous page of 270 mm by 215 mm, with sixty coloured and black-and-white illustrations of her work supporting the text. Just 100 numbered and signed copies have been Indigo printed on 140 gsm Fedrigoni Arena. The full-cloth, sewn, and cased binding carries the title on the spine and comes in a laminated dustjacket.

Table of Contents:
Introduction
Chapter 1: Marmalade sans serif
Chapter 2: The early books
Chapter 3: The Almorah Road years
Chapter 4: A certain recognizable aesthetic
Chapter 5: the business of the books
Catalogue Raisonné
University and Library Collections
Bibliography
General Index
Title Index

• Shorvon, S., Guerrini, R., Schachter, S., & Trinka, E. (Eds.).
• Cambridge: Cambridge University Press, 2019
• Pages 989
• ISBN: 978-1-108-42075-4 Hardback
• 09

Description

The identification of the cause of an epileptic seizure is a key element in the clinical management of all patients. In recent decades, advances in theory, neuroimaging, molecular genetics and molecular chemistry have revolutionized our ability to investigate and identify the underlying cause. The definitive and unrivalled textbook on the causes of epilepsy, this second edition is extensively revised and expanded. It provides concise descriptions of all the major genetic and acquired conditions that cause epilepsy in adults and children, and the provoking factors for epileptic seizures and of the causes of status epilepticus. A new section considers clinical approaches to diagnosing causes, to guide and assist clinicians in investigations. With 128 chapters written by leading figures from around the world, this comprehensive and authoritative resource is indispensable to senior and junior clinicians and trainees working in the field of epilepsy, including specialists in neurology, paediatrics, neurophysiology, psychiatry and neurosurgery.

Contents

Part I: Introduction
1. Concept of Causation in Epilepsy
2. Epileptogenesis in Idiopathic Epilepsy
3. An introduction to Epilepsy Genetics
4. Epileptogenesis in Symptomatic Epilepsy
5. Animal Models of Epilepsy

Part II: Approaches to the Clinical Investigation and Diagnosis of Cause
6. Approach to the Diagnosis of Neonatal Seizures
7. Approach to the Genetic Diagnosis of Epileptic Encephalopathies and Developmental Encephalopathies with Epilepsy of Early Childhood
8. Approach to the Diagnosis of Childhood-onset Epilepsy Associated with Developmental Delay
9. Approach to the diagnosis of cortical developmental disorders and their clinical genetics
10. Approach to the diagnosis of the Inborn Errors of Metabolism Associated with Epilepsy and their Clinical genetics
11. Approach to the Diagnosis of Epilepsy Presenting with Myoclonus
12. Approach to theDiagnosis of Epilepsy Syndromes with Multiple Causes
13. Approach to the Diagnosis of Causation in Epilepsy in Adults

Part III: Idiopathic Epilepsies: Pure Epilepsies without Known Cause
14. Idiopathic Generalized Epilepsies
15. Benign Partial Epilepsies of Childhood

Part IV (a): Symptomatic Epilepsies of Genetic or Developmental Origin: Single Gene Disorders and Inborn Errors of Metabolism
16. Benign Familial Neonatal Epilepsy (BFNE)
17. Sleep-related Hypermotor Epilepsy (SHE)
18. Genetic Epilepsy with Febrile Seizures Plus (GEFS+)
19. Dravet Syndrome and Other SCN1A Disorders
20. Familial Lateral Temporal Lobe Epilepsy
21. Familial Focal Epilepsy with Variable Foci
22. PCDH19 Mutations Related Epilepsy: phenotype and genotype
23. CDKL5 Encephalopathy
24. KCNQ2 Encephalopathy
25. FOXG1 Encephalopathy
26. STXBP1 Encephalopathy
27. Rett Syndrome
28. GLUT1 Deficiency Syndrome
29. Other Rare Single-gene Disorders Causing Epileptic Encephalopathy
30. Mitochondrial Epilepsies
31. Lysosomal Disorders and Epilepsy
32. Peroxisomal disorders and epilepsy
33. Menkes’ Disease
34. Neuroacanthocytosis
35. Organic acid and Amino Acid Metabolism Disorders
36. Porphyrias
37. Pyridoxine-Dependent Epilepsy
38. Fatty Acid Oxidation Disorders
39. GABA Metabolism Deficiency Syndromes
40. Disorders of Creatine Metabolism and Epilepsy
41. Epilepsy Caused by Congenital Disorders of Glycosylation
42. Urea Cycle Disorders
43. Hyperinsulinism-hyperammonaemia and Biotin Pathway Defects
44. Other Single Gene Disorders

Part IV (b): Symptomatic Epilepsies of Genetic or Developmental Origin: Progressive Myoclonic Epilepsies
45. Unverricht–Lundborg disease (or progressive myoclonus epilepsy type 1)
46. Dentatorubral-pallidoluysian atrophy; DRPLA
47. Lafora Body Disease
48. Epileptic Syndromes in Mitochondrial Disease
49. Neuronal Ceroid Lipofuscinoses
50. Sialidosis
51. Progressive Myoclonic Epilepsies: other rarer causes

Part IV (c): Symptomatic Epilepsies of Genetic or Developmental Origin: Neurocutaneous Syndromes
52. Tuberous Sclerosis Complex
53. Neurofibromatosis
54. Sturge-Weber Syndrome
55. Other Neurocutaneous Syndromes

Part IV (d): Symptomatic Epilepsies of Genetic or Developmental Origin: Epilepsies Associated with Chromosomal Abnormalities
56. Copy Number Variations Causing Epilepsy
57. MECP2 Duplication Syndrome
58. Down Syndrome
59. Fragile X Syndrome
60. 4p Deletion (Wolf–Hirschhorn) Syndrome
61. Inverted Duplicated Chromosome 15 (Isodicentric Chromosome 15)
62. Ring Chromosome 20
63. Ring Chromosome 14 and Other Rare Ring Chromosomal Disorders
64. Angelman Syndrome

Part IV (e): Symptomatic Epilepsies of Genetic or Developmental Origin: Epilepsies Associated with Developmental Anomalies of Cerebral Structure
65. Hemimegalencephaly
66. Focal Cortical Dysplasia
67. Agyria–pachygyria Band spectrum
68. Corpus Callosum and Epilepsies
69. Polymicrogyria and Schizencephaly
70. Periventricular Nodular Heterotopia
71. Microcephaly
72. Arachoid Cysts
73. Disorders Associated with Tubulinopathies and motoropathies

Part V (a): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Cerebral Trauma
74. Epilepsy Associated with Head Injury
75. ‘De Novo’ Epilepsy after Neurosurgery
76. Epilepsy after Epilepsy Surgery
77. Epilepsy after Abusive Head Trauma

Part V (b): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Cerebral Tumours
78. Epilepsy Associated with Glioma
79. Epilepsy Associated with Ganglioglioma, Dysembryoplastic Neuroepithelial Tumor, and Related Tumors
80. Hypothalamic Hamartoma and Gelastic Epilepsy
81. Epilepsy Associated with Meningioma
82. Metastatic Disease

Part V (c): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Cerebral Infection
83. Epilepsy Associated with Viral Encephalitis
84. Bacterial Meningitis and Focal Suppurative Intracranial Infections in Children
85. Bacterial Meningitis and Pyogenic Abscess in Adults
86. Epilepsy Associated with Malaria
87. Epilepsy Associated with Neurocysticercosis
88. Other Parasitic Diseases
89. Epilepsy Associated with Tuberculosis
90. HIV and Seizures
91. Emerging and Less Common Central Nervous system Viral Encephalitides

Part V (d): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Cerebrovascular Disease
92. Epilepsy Associated with Intracerebral Hemorrhage
93. Epilepsy Associated with Subarachnoid Hemorrhage
94. Epilepsy and Cerebrovascular Disease
95. Epilepsy Associated with Arteriovenous Malformations
96. Epilepsy Associated with Cavernous Malformations
97. Epilepsy Associated with Other Vascular Disorders

Part V (e): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Cerebral Immunological Disorders
98. Rasmussen’s Encephalitis and Related Conditions
99. Epilepsy Associated with Systemic Lupus Erythematosus and Other Collagen Vascular Diseases
100. Epilepsy Associated with Inflammatory and Immunological Diseases of the Central Nervous System
101. Epilepsy in Multiple Sclerosis and Other Acquired Demyelinating Diseases
102. Immune-Mediated Epilepsy

Part V (f): Symptomatic Epilepsies of Acquired Origin: Epilepsies Associated with Other Cerebral Disorders
103. Hippocampal Sclerosis
104. Epilepsy Associated with Psychiatric Disorders
105. Hydrocephalus and Porencephaly
106. Epilepsy Associated with Alzheimer’s Disease and Other Adult Neurodegenrative
Disorders
107. Epilepsy Associated with Eclampsia and the Posterior Reversible Encephalopathy
Syndrome
108. Cerebral Palsy
109. Seizures and Epilepsy Associated with Pertussis and Other Vaccinations

Part VI: Provoking Factors and Provoked Epilepsies: Reflex Seizures
110. Fever as a Precipitating Factor for Epileptic Seizures
111. The Menstrual Cycle and Catamenial Epilepsy
112. Sleep and Epilepsy
113. Electrolyte and Sugar Disturbances
114. Drug-Induced Seizures
115. Recreational and illicit drugs causing seizures and epilepsy
116. Alcohol- and Toxin-Induced Seizures
117. Visual Stimuli, Photosensitivity and Photosensitive Epilepsy
118. Startle-Induced and Other Sensory-Induced Epilepsy
119. Primary Reading Epilepsy
120. Auditory-Induced Epilepsy
121. Seizures Induced by Eating, a Rare but Special Form of Reflex Epilepsy
122. Hot Water Epilepsy
123. Reflex Epilepsy with Higher-Level Processing

Part VII: Status Epilepticus
124. The Causes of Status Epilepticus in Children
125. The Common Causes of Convulsive Status Epilepticus in Adults
126. Uncommon Causes of Status Epilepticus
127. Causes of Nonconvulsive Status Epilepticus in Adults
128. The Causes of Epilepsia Partialis Continua

Link to Table of Contents

Simon Shorvon, Alastair Compston
Cambridge University Press, 2019
Pages: 561
ISBN: 978 1 107 10082 4 (Hardback)
Online ISBN: 781316181430
https://doi.org/10.1017/9781316181430

Description

As the first neurological hospital in the world, founded in 1859, the National Hospital, Queen Square, and its affiliated Institute of Neurology remain leading neurological centres providing exceptional clinical services, teaching and research. Illustrated by over 100 historical images and much unpublished archival material, this book provides a comprehensive history of the National Hospital, the Institute, and their staff. It relates the ups and downs of the Hospital and Institute in war and peacetime, their financial struggles, many personality conflicts, efforts to remain independent and to maintain neurological dominance, academic and clinical contributions, issues relating to specialisation and sub-specialisation and relations between disciplines, and the changing roles of the Hospital and Institute. The history is told from varying perspectives against the backdrop of the evolution of British clinical neuroscience, the special position of London medicine, and the influence of world wars, and is set in the context of modern British social history.

Table of contents

Introduction

Chapter 1: Foundation and Making of the National Hospital

Chapter 2: Queen Square, the Salmon Pink and Other Hospital Buildings

Chapter 3: Queen Square and Neurology 1860–1902

Chapter 4: National Hospital Quadrumvirate

Chapter 5: Roller-coaster Ride and the National Hospital Rubs Along 1902–1945

Chapter 6: Five Dominant Physicians

Chapter 7: The NHS Arrives and the Hospital Celebrates its Centenary 1946–1962

Chapter 8: Beyond the Walls: British Neurology Outside Queen Square

Chapter 9: Neurosurgery and War Neurology at Queen Square

Chapter 10: Other Clinical Specialties at Queen Square

Chapter 11: The Investigatory Specialties at Queen Square

Chapter 12: The Medical School and the Institute of Neurology

Chapter 13:  The Rise of Academic Neurology at Queen Square 1962– 1997

Chapter 14:  Never, Never, Ever –  Change and Integration 1962– 1997

Edited by Linda Luxon and Simon Shorvon with Julie Beckwith
Third Millennium Publications, March 2018
ISBN: 978 1 781259 11 5
Pages: 192
Illustrations: Over 400

Description

This large format hardback book narrates the history of the Royal College of Physicians, from its foundation and survival through a turbulent history to its position today as a leading international body for physicians. This book takes a chronological approach, showing the development of the college within the wider social landscape of great upheaval and innovation. Designed by Third Millennium Publications, it has striking photography and is heavily illustrated with specially curated archival images.

Table of Contents:

Introduction

Chapter 1: Antecedents

Chapter 2: The foundation and rise of the College 1518-1660

Chapter 3: Calamity and conflict 1660-1740

Chapter 4: Enlightenment 1740-1820

Chapter 5: Reform and regulation 18820-1880

Chapter 6: Modernisation 1880-1948

Chapter 7: A brave experiment 1948-2018

Chapter 8: The College in a changing world

Appendices: Index, list of subscribers, picture credits.

Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon
Wiley Blackwell, 2016
ISBN: 978-1-118-48617-7
1096 pages

Description

Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neurosciences

• A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research
• Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective
• Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology
• All chapters fully revised and updated to reflect the increasing role of neurologists in acute care
• Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson’s disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitation for dementia, epilepsy, headaches, neuro-genetics and many more

Table of Contents

1 Neurology Worldwide: The Epidemiology and Burden of Neurological Disease
Simon Shorvon

2 Nervous System Structure and Function
Charles Clarke and Roger Lemon

3 Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels
Dimitri Kullmann, Henry Houlden and Michael Lunn

4 The Language of Neurology: Symptoms, Signs and Basic Investigations
Charles Clarke, Matthew Adams, Robin Howard, Martin Rossor, Simon Shorvon and Jason Warren

5 Stroke and Cerebrovascular Diseases
Nicholas Losseff, Matthew Adams, Martin M. Brown, Joan Grieve and Robert Simister

6 Movement Disorders
Kailash Bhatia, Carla Cordivari, Mark Edwards, Thomas Foltynie, Marwan Hariz, Prasad Korlipara, Patricia Limousin, Niall Quinn, Sarah Tabrizi and Thomas Warner

7 Epilepsy and Related Disorders
Simon Shorvon, Beate Diehl, John Duncan, Matthias Koepp, Fergus Rugg-Gunn, Josemir Sander, Matthew Walker and Tim Wehner

8 Dementia and Cognitive Impairment
Martin Rossor, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Jonathan Schott and Jason Warren

9 Infection in the Nervous System
Robin Howard, Carmel Curtis and Hadi Manji

10 Nerve and Muscle Disease
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Shamima Rahman, Mary Reilly, Katie Sidle and Christopher Turner

11 Multiple Sclerosis and Demyelinating Diseases
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller and Alan Thompson

12 Headache
Manjit Matharu, Paul Shanahan and Tim Young

13 Cranial Nerve Disorders
Jeremy Chataway, Charles Clarke, Robin Howard and Paul Jarman

14 Neuro-ophthalmology
James Acheson, Fion Bremner, Elizabeth Graham, Robin Howard, Alexander Leff, Gordon Plant, Simon Shorvon and Ahmed Toosy

15 Neuro-0tology: Problems of Dizziness, Balance and Hearing
Rosalyn Davies, Linda M. Luxon, Doris ]Eva Bamiou and Adolfo Bronstein

16 Spinal Column and Spinal Cord Disorders
Simon Farmer and David Choi

17 Cerebellar Ataxias and Related Conditions
Nicholas W. Wood

18 Restorative Neurology, Rehabilitation and Brain Injury
Richard Greenwood, Diana Caine, Ulrike Hammerbeck, Alexander Leff, Diane Playford, Valerie Stevenson and Nick Ward

19 Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism
Robin Howard, Jeremy Chataway, Mark Edwards, Simon Heales, Robin Lachmann, Alexander Leff and Elaine Murphy

20 Disorders of Consciousness, Intensive Care Neurology and Sleep
Robin Howard, Sofia Eriksson, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Christopher Taylor and Matthew Walker

21 Neuro-oncology
Jeremy Rees, Robert Bradford, Sebastian Brandner, Naomi Fersht, Rolf Jäger and Elena Wilson

22 Neuropsychiatry
Eileen Joyce

23 Pain
Paul Nandi

24 Autonomic Aspects of Neurology
Christopher Mathias, Gordon Ingle and Valeria Iodice

25 Uroneurology
Jalesh Panicker

26 Systemic Conditions and Neurology
David Werring, Robin Howard and Simon Shorvon

Index 1029

Humphrey Hodgson and Simon Shorvon
Little Brown 2016
ISBN-10: 1408706288; ISBN9781408706282
112 pages

Description

The Royal College of Physicians celebrates its 500th anniversary in 2018, and to observe this landmark is publishing a series of ten books. Each of the books focuses on fifty elements that have contributed to making the RCP what it is today.  This, the fourth book, outlines some of the effects of war on the College as an institution, on it’s buildings and especially on its members and fellows. Medicine can profoundly change the fortunes of those engaged in war, and war also greatly changes medicine. It creates new diseases, leads to medical innovation and advances in therapy, and has also stimulated new approaches to the organisation of medical care. This book is a brief exposition on aspects of the complex interface of war and medicine, and the crucial role played by the College and its physicians in the medicine of war.

Table of Contents

Introduction

The turbulent seventeenth century

Napoleonic wars and the alter nineteenth century

World War I

World War II

Postscript

Dieter Schmidt and Simon Shorvon
Oxford University Press, 2016
ISBN-10: 0198725906; ISBN-13: 9780198725909
208 pages

Description

Epilepsy is more than just a physical condition, the fact of simply having epileptic seizures, it has cultural, geographic and historical meaning and significance which go beyond that of a neurological disorder, and which defy a single perspective. The End of Epilepsy? is a beautifully illustrated, authoritative, and engaging history of medical developments during the modern era of epilepsy, which began with the introduction of Bromides and Hughlings-Jacksons definition of epilepsy in 1860.

Table of Contents

1: What is epilepsy?
2: Attitudes
3: The pharmaceutical phoenix rises
4: Modern blockbusters
5: Resecting epilepsy
6: The dark side of epilepsy
7: Culs-de-sac and bureaucracies
8: Is the end of epilepsy in sight?
Appendix: Dating epilepsy
Index

 

 

 

Editors: Krishnamoorthy ES, Shorvon SD, Schachter S
Cambridge University Press; 1 edition (6 April 2017)
ISBN-10: 1107035376, ISBN-13: 978-1107035379
232 pages

Description

A multidisciplinary approach to epilepsy compares and contrasts scientific knowledge, clinical experience and social consciousness between Western and non-Western cultures, enhancing transcultural understanding and providing a paradigm for an integrative, truly global health policy for this disorder. Topics covered include pharmacological and non-pharmacological management of epilepsy; care models and traditional medical systems; service organization in resource-limited countries; cultural perspectives on consequences of epilepsy; social, anthropological, economic, political, and spiritual issues related to living with epilepsy; infectious and non-infectious causes and risk-factors; region-specific syndromes. Uniquely drawing attention to both a medical perspective and the burden of living with epilepsy, this is a must-have reference work for epileptologists, neurologists, epidemiologists, medical policymakers and health administrators in both the developed and developing world.

Paperback: 404 pages
Publisher: Cambridge University Press; 1 edition (November 2, 2006)
Language: English
ISBN-10: 0521031141
ISBN-13: 978-0521031141

Status epilepticus, the maximum expression of epilepsy, is a distinctive condition, much more than simple a severe version of ordinary epilepsy. This is the definitive reference work on the subject, taking a modern look at the clinical features, pathophysiology and treatment of status, in both children and adults.

All forms of status are considered, including the classical convulsive (grand mal) type, the less well-understood yet common and fascinating nonconvulsive variants, boundary syndromes and also pseudostatus epilepticus. The history, clinical aspects, treatment and outcome of each form are explored in their scientific content, accounting for research findings in the fields of epidemiology, neurophysiology, neuroanatomy, neuropathology, neurochemistry and neuropharmacology. Received ideas are examined critically, the existing schemes of classification revised, and current practice is challenged where it seems inadequate.

Treatment is dealt with in depth, and schemes of management outlined for both convulsive and nonconvulsive forms. For each drug used in status, a systematic review is given of the pharmacology, clinical and toxic effects in status, administration and dosage. Summary tables outline key clinical information.

The text is based on extensive clinical experience of the author, and a practical and theoretical perspective is taken throughout. The world literature is expertly marshalled to provide a comprehensive review of the topic in all its aspects. The book is therefore both a reference work and a practical guide, useful for a wide range of clinicians, neurologists, psychiatrists, paediatricians, other specialists and generalists, and all those dealing with emergency and intensive care medicine.

CONTENTS

1: The concept of status epilepticus and its history
Pre-history of status epilepticus
Origins of status epilepticus
Classical descriptions of status epilepticus
Era of electroencephalography
Les Colloques de Marseille, and the definition and classification of status epilepticus

2: Definition, classification and frequency of status epilepticus
Definition of status epilepticus
Classification of status epilepticus
A new classification of status epilepticus
Frequency of status epilepticus
Population estimates of the frequency of status epilepticus

3: Clinical forms of status epilepticus
Status epilepticus confined to the neonatal period
Neonatal status epilepticus
Status epilepticus in neonatal epilepsy syndromes
Status epilepticus confined largely to infancy and childhood
Infantile spasm (West syndrome)
Febrile status epilepticus
Status in childhood myoclonic epilepsies
Status epilepticus in the benign childhood epilepsy syndromes
Electrical status epilepticus during slow wave sleep
Syndrome of acquired epileptic aphasia (Landau-Kleffner or Worster-Drought syndrome)
Status epilepticus occurring in late childhood and adult life
Tonic-clonic status epilepticus
Absence status epilepticus
Epilepsia partialis continua
Myoclonic status epilepticus in coma
Specific forms of status epilepticus in mental retardation
Other syndromes of myoclonic status epilepticus
Nonconvulsive simple partial status epilepticus
Complex partial status epilepticus
Boundary conditions
Status epilepticus confined to adult life
De novo absence status epilepticus of late onset
Pseudostatus epilepticus

4: Neurophysiology, neuropathology and neurochemistry of status epilepticus
Experimental neurophysiology of status epilepticus
Neuropathology of status epilepticus
Neurochemistry of status epilepticus

5: Emergency treatment of status epilepticus
General measures
Antiepileptic drug pharmacokinetics in status epilepticus
Drug absorption
Drug distribution, metabolism and excretion
Blood levels and interactions
Ideal antiepileptic drug in tonic-clonic status epilepticus
Stages of drug treatment in tonic-clonic status epilepticus, and drug treatment regimens
Failure of antiepileptic drug treatment
Antiepileptic drugs used in status epilepticus
Premonitory status epilepticus
Diazepam
Midazolam
Paraldehyde
Early and established status epilepticus
Chlormethiazole (chlomethiazole)
Clonazepam
Lignocaine (lidocaine)
Lorazepam
Phenytoin
Phenobarbitone (phenobarbital)
Stage of refractory status epilepticus: general anaesthesia
Thiopentone sodium (thiopental sodium)
Pentobarbitone sodium (pentobarbital sodium)
Isoflurane
Etomidate
Propofol
Other drugs used in status epilepticus
Emergency treatment of other forms of status epilepticus
Prologue to therapy in status epilepticus

6: Prognosis and outcome of status epilepticus
Outcome of tonic-clonic status epilepticus (including generic studies of status epilepticus)
Outcome of other syndromes of status epilepticus